The Sun Protective Effect of Melatonin

• Status: Completed
• Trial end date: 2013-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to investigate the sun protective effect of melatonin, when used as a cream applied before sun exposure.

Sun exposure induces erythema as indication of an inflammatory reaction in the skin. It is proven that the amount of free radicals in the skin are increased by UV exposure. Furthermore, it is known that melatonin is a potent antioxidant. It is hypothesized that melatonin can be protective against the UV induced release of free radicals by acting as a radical scavenger and thereby protect against UV-induced cellular damage.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Herlev Hospital
• Treatments: Melatonin

Criteria

Inclusion Criteria:

• Healthy volunteers of both sexes.

• Skin type 1-3 according to Fitzpatrick skin type scale.

• No sun exposure on skin area tested in the study 4 weeks prior to the study.

Exclusion Criteria:

• Active skin disease

• Participant that do not react to the given sun exposure with a change in a-value >5 are excluded from the data.

• Pregnancy

• Previous malignant or pre malignant skin disease.