The Therapeutic Effects of Insulin and Berberine on Stress Hyperglycemia

• Status: Unknown status
• Trial end date: 2017-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Berberine is a conventional component in Chinese medicine. In recent years, effects of Berberine on improvement of glucose metabolism have been explored. The purpose of this study is to observe the therapeutic effects of combination of insulin and berberine on stress hyperglycemia in patients after cardiac surgery.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangdong General Hospital; Guangdong Provincial People's Hospital
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• Clinical diagnosis of stress hyperglycemia (fasting glucose >6.9 mmol/L or random glucose >11.1 mmol/L without evidence of previous diabetes);

• Worsening glycemic control;

• Individuals who had cardiac surgery before recruitment;

• Those who voluntarily sign the consent form after being fully informed and understanding the purpose and procedures of the study, characters of the disease, effect of medications, methods of related examinations, and potential risk/benefits of the study;

Exclusion Criteria:

• Individuals with a history of diabetes;

• Individuals who are not able to cooperate;

• Female of childbearing potential;

• Severe liver or renal disease, or cancer history;

• Individuals who are involved in designing, planning or performing this clinical trial;

• Individuals with any condition that could be worsened by supplemental Berberine;

• Individuals with severe gastrointestinal disease;

• Individuals with infectious diseases;

• Current participation in another clinical trial;