The Thiamine Administration After Cardiac Surgery Trial
Status:
Recruiting
Trial end date:
2021-12-30
Target enrollment:
Participant gender:
Summary
Thiamine (Vitamin B1) is essential for cell function and as a co-factor of the enzyme
Pyruvate Dehydrogenase to initiate the Krebs cycle and thus the aerobic metabolism of
glucose.
We hypothesize that thiamine supplementation improves the clearance of lactate in the first
24 hours after cardiac surgery with extracorporeal circulation in patients with high lactate
concentration.