The Tolerability and Pharmacokinetics of Multiple Doses of SPH3127 in Chinese Healthy People

• Status: Unknown status
• Trial end date: 2018-09-20
• Target enrollment: 0
• Participant gender: All

Summary

This study was a single center, parallel, randomized, double blind, placebo-controlled phase Ib clinical trial to to evaluate the safety and tolerability and pharmacokinetics of SPH3127 tablet in healthy subjects by increasing multiple dosing

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Shanghai Pharmaceuticals Holding Co., Ltd

Criteria

Inclusion Criteria:

1. The body mass index is 18-28kg/m2 (including the critical value), which allows the minimum weight of men to be 50kg (including the critical value) and 45kg for women (including the critical value).

2. Before the study,participant has know about the significance , potential benefits, inconveniences and potential risks of the study

3. Participant has understood the research's procedure and sign the informed consent .

Exclusion Criteria:

• Participant who are Pregnancy, lactating women, and planned trials begin within six months of pregnancy

• Participant who has abnormal Physical examination, laboratory examination results and clinical significance (such as: liver function examination - aspartate aminotransferase (AST) and alanine aminotransferase (ALT) more than 1.5 times that of the upper limit of normal)

• Participant who has a history of cardiovascular, liver, kidney, digestive tract, nervous system, blood system, familial hematologic disease, abnormal thyroid function, or mental abnormality

• Participant who has drug allergy history and anaphylactic reaction

• Participant who took oral contraceptive in 6 months

• Participant who used any drug (including Chinese herbal medicine) within 1 week.

• Participant who donated blood within 2 months

• Participant who participated clinical trials of any drug in 3 months (as subjects)

• Participant who has any positive result of virus serology check: human immunodeficiency virus antigen antibody (HIV Ag/Ab) and hepatitis c virus (HCV) - immunoglobulin G(IgG) antibody to IgG, hepatitis b surface antigen (HBsAg) and treponema pallidum antibody (TP)

• Participant who are used to smoke, alcohol abuse, eat coffee and strong tea and drug abuse

• Participant who the researchers believe that there are volunteers who are not suitable for the study