The Treatment of Periodontal Diseases

• Status: Unknown status
• Trial end date: 2016-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine if the correct use of antibiotics, as well as the application of one-day-treatment, in the therapy of periodontal diseases. The population of treated patients (184) are divided in 4 groups; Group 1: Metronidazole + mechanical treatment in one day, Group 2: Placebo + mechanical treatment in one day Group 3: Metronidazole + mechanical treatment on day 1 and 21 Group 4: Placebo + mechanical treatment on day 1 and 21 End points, BOP, Plaque, PPD, CAL, RAL, Microbiology will be recorded on all sites at 3 months, 1 -, 3 -, and 5 years post-treatment

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Oslo
• Collaborator: The Research Council of Norway
• Treatments: Metronidazole

Criteria

Inclusion Criteria:

• Females and males with advanced periodontal disease referred between November 2007 and January 2009.

• No diseases known to be associated with periodontal diseases, i.e. diabetes mellitus, rheumatoid arthritis, pregnancies.

• No continuous medication known to affect the severity or progression of periodontal diseases.

• No previous systematic periodontal treatment.

• More than 5 pockets 5mm < PPD < 9 mm after a 3 month hygiene phase - i.e. before inclusion into study.

• Oral hygiene; < 5% of surfaces with plaque at inclusion time.

• Signing an informed consent.

Exclusion criteria:

• diseases known to be associated with periodontal diseases, i.e. diabetes mellitus, rheumatoid arthritis.

• pregnancy

• continuous medication known to affect the clinical expression of periodontal diseases

• subgingival microbiological diagnosis which reveals bacteria with reduced/no sensitivity to metronidazole