The Use of Ambulatory Blood Pressure Monitors to Assess Angiotensin Converting Enzyme Inhibitors

• Status: Unknown status
• Trial end date: 2018-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to use ambulatory blood pressure monitors to investigate whether enalapril is superior to lisinopril in managing nocturnal hypertension in patients with resistant hypertension currently treated with daytime angiotensin converting enzyme inhibitors.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Memorial Health University Medical Center
• Treatments: Angiotensin-Converting Enzyme Inhibitors; Enalapril; Enalaprilat; Enzyme Inhibitors; Lisinopril

Criteria

Inclusion Criteria:

• Patients with clinic blood pressure > 140/90 mm Hg on 3 antihypertensives or clinic blood pressure < 140/90 mm Hg on 4 antihypertensives

• Currently treated with an angiotensin converting enzyme inhibitor

Exclusion Criteria:

• Chronic kidney disease (CKD) stage 4 or worse

• Pheochromocytoma

• Unstable cardiovascular disease Stroke, Transient Ischemic Attack, Unstable Angina, or Myocardial infarction in the last 30 days

• Hyperaldosteronism

• Current pregnancy

• Shift worker at night

• Presenting blood pressure > 180/110 mm Hg