The Use of Anti-oxidants to Reduce Sequela of Mild Traumatic Brain Injury (mTBI) After Blast Exposure

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The administration of N-acetyl-cysteine (an anti-oxidant) for seven days along with observation will result in improved hearing and balance function in individuals who demonstrate these disorders after blast exposure when compared to a placebo medicine and observation at the seven day time point.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Brooke Army Medical Center
• Treatments: Acetylcysteine; Antioxidants; N-monoacetylcystine

Criteria

Inclusion Criteria:

1. Be active duty United States Service member

2. Be between the ages of 18 and 50 years

3. Present to TQ Surgical within 24 hours of blast exposure.

4. Have complains consistent with possible TBI including hearing loss, dizziness, lightheadedness, cognitive difficulties, and/or had loss of consciousness.

5. Are not expressly excluded by the criteria listed below.

Exclusion Criteria:

1. Require urgent or emergent surgical procedures.

2. Will require medical evacuation to any level III or higher facility (other then to a level III for a CT scan only).

3. Has evidence of an open head wound.

4. Pregnant Females

5. The use, within the last seven days, of a nutritional supplement containing an anti-oxidant.