The Use of Antimicrobial Agents in the Inhibition of Mutans Streptococci in Children With Dental Caries
Status:
Completed
Trial end date:
2006-10-01
Target enrollment:
Participant gender:
Summary
The aim of the present study was to compare salivary MS levels in four different groups of
children with caries, that have been submitted to intraoral topical treatment with either
1,23% sodium fluoride, 1% chlorhexidine, 3% or 10% vancomycin, during 6 consecutive days.
This clinical trial was designed to test two different hypotheses. First, that topical
vancomycin would be more effective than chlorhexidine and sodium fluoride in salivary MS
reduction. Secondly, a 6-day antimicrobial treatment with either one of these agents would
produce a long lasting MS suppression, dispensing repeated antibacterial treatments.