The Use of Brazilian Green Propolis Extract (EPP-AF) in Patients Affected by COVID-19.
Status:
Completed
Trial end date:
2020-08-30
Target enrollment:
Participant gender:
Summary
The COVID-19 pandemic is of grave concern due its impact on human health and on the economy.
Propolis, a natural resin produced by bees from plant materials, has anti-inflammatory,
immunomodulatory, anti-oxidant properties, and various aspects of the SARS-CoV-2 infection
mechanism are potential targets for propolis compounds. Propolis components have inhibitory
effects on the ACE2, TMPRSS2 and PAK1 signaling pathways; in addition, antiviral activity has
been proven in vitro and in vivo. This is a pilot randomized study that aims to assess the
impact of using Brazilian green propolis extract against the deleterious effects of the new
coronavirus.