The Use of Erythritol Powder and Metronidazole Gel for the Non-surgical Treatment of Periodontitis
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
Aim of the present study is evaluate the use of erythritol powder with/without the adjunct of
local metronidazole in the treatment of periodontal pockets.
20 consecutive adult periodontal patients, requiring cause-related therapy as phase 1 of
their treatment plan, and presenting ≥4 sites with probing pocket depth ≥4mm will be
enrolled. For each patients four sites will be considered for the study, and two sites will
be allocated in the test group and two sites will be allocated in the control group. In the
test group, ultrasonic debridement of the pocket will be performed using a piezoceramic
ultrasonic device with the a tip connected to the handpiece for 5 minutes/pocket. Then, it
will be followed by the subgingival use of erythritol powder 2x5 seconds/pocket. At this time
the subgingival delivery of metronidazole gel will be provided. In the control group, the
same protocol will be used except for the use of a placebo instead of metronidazole. After
instrumentation, patients will rinse with chlorhexidine 0.20% 3 times/day for 2 weeks.
At baseline, 1 month, 3 months and 6 months the following parameters will be evaluated:
Probing Pocket depth (PPD), Bleeding on Probing (BoP), Clinical Attachment Level (CAL).