The Use of Fibrin Sealant to Reduce Bleeding After Total Knee Replacement

• Status: Completed
• Trial end date: 2012-06-01
• Target enrollment: 0
• Participant gender: All

Summary

A randomized controlled study is performed to address the question of whether the topical application of a novel fibrin sealant, Evicel (Johnson & Johnson Wound Management, Ethicon, Somerville, NJ) in patient undergoing total knee replacement (TKR) reduce the perioperative blood loss and the need for allogenic blood transfusion compared to a control group. We hypothesize that fibrin sealant decrease the drop in post-operative hemoglobin level after total knee replacement.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Milan
• Treatments: Fibrin Tissue Adhesive

Criteria

Inclusion Criteria:

• patient scheduled for TKR

• written informed consent

• diagnosis of osteoarthritis

Exclusion Criteria:

• previous intervention on the same Knee (except for meniscectomy)

• Hb pre-operative level lower than 12g/dl for man and 11g/dl for woman

• Anticoagulation therapy or any anti-aggregate treatment not suspended at least 4 days before surgery