The Use of Glyceryl Trinitrate Patches in Arteriovenous Fistulas

• Status: Completed
• Trial end date: 2015-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the study is to determine whether the application of a glyceryl trinitrate patch (GTN patch) helps arteriovenous fistulas, created for renal dialysis access, mature so that they can be used.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University Hospital Birmingham
• Treatments: Nitroglycerin

Criteria

Inclusion Criteria:

• Primary arteriovenous fistulas

• Brachiocephalic

• Radiocephalic (both proximal and distal)

• >18 yrs old

• Diabetics and smokers will be eligible for inclusion

Exclusion Criteria:

• All complex vascular access procedures

• Re-do brachiocephalic and radiocephalic fistulas

• Brachiobasilic fistulas

• Prosthetic grafts

• Cardiovascular dysfunction

• Hypotension (systolic <90)

• Obstructive Cardiomyopathy

• Severe Aortic stenosis (gradient >40mmhg)

• Confirmed myocardial infarction within the last 6 months

• Marked anaemia (Hb<8)

• Migraine

• Medications

• Sildenafil

• Pre-existing nitrate use

• Nitrate allergy

• Closed-angle glaucoma

• Chronically raised intra-cranial pressure

• History of hypothyroid disease

• < 18 years old