The Use of Intralipid® 20% Solution to Reverse the Anesthetic Effect of Local Anesthetics: a Proof of Concept Study in Volunteers

• Status: Enrolling by invitation
• Trial end date: 2022-12-01
• Target enrollment: 0
• Participant gender: All

Summary

In order to determine if Intralipid 20% can be used to reverse the effects of local anesthetics, the investigators will recruit 18 volunteers who will be asked to come to HSS for two study visits. Small amounts of local anesthetics will be injected into the volunteers' thighs during both visits. During one visit volunteers will receive Intralipid 20% and during the other visit they will receive a saline solution. The study team will measure how quickly normal sensation returns to the thighs when the volunteers get Intralipid 20% compared to saline.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Hospital for Special Surgery, New York
• Treatments: Anesthetics; Anesthetics, Local; Bupivacaine; Lidocaine; Pharmaceutical Solutions; Soybean oil, phospholipid emulsion

Criteria

Inclusion Criteria:

• English speaking

• BMI 18-25, with body weight between 50-100kg

Exclusion Criteria:

• ASA III or higher

• Pregnant Women

• Allergy to study medications (lidocaine, bupivacaine, soybeans, eggs)

• Use of drugs affecting the sensorium (including opioids, benzodiazepines, antipsychotics, gabapentinoids)