The Use of Propranolol to Block Memory Reconsolidation in PTSD

• Status: Terminated
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

The purpose of this investigation is to see if propranolol will reduce the psychophysiological hyperactivation associated with memories of combat stress in Veterans with Posttraumatic Stress Disorder.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Wayne State University
• Collaborators: John D. Dingell VA Medical Center; New York University
• Treatments: Propranolol

Criteria

Inclusion Criteria:

• Participants will meet the clinical criteria of PTSD (DSM IVTR) secondary to combat exposure.

Exclusion Criteria:

• Current illicit substance use or alcohol consumption, as determined by urine toxicology and alcohol breath test.

• Any diagnosis of current comorbid psychotic disorders, bipolar disorder, or illicit substance or alcohol abuse or dependence.

• Any current prescription medication usage or supplement (dietary or herbal) usage that is contraindicated with propranolol.

• Active enrollment into any psychiatric or psychological treatment.

• Any condition that contraindicates the use of propranolol, such as:

• history of bronchial asthma.

• heart block.

• sinus bradycardia.

• congestive heart failure.

• insulin-dependent diabetes.

• initial systolic blood pressure < 100 mmHg.

• Hyperthyroidism.

• Thyroid disease.

• Renal or liver impairment.