Overview

The Use of Prostaglandin E1 in Head and Neck Microsurgery

Status:
Unknown status

Trial end date:
2010-07-01

Target enrollment:
0

Participant gender:
All

Summary

Prostaglandin E1 (PGE1 )has been shown to have vasodilatation and anti-thrombosis effects, so it is used by some surgeons after microsurgery to keep the patency of the anastomosed small vessels. However, PGE 1 may also causes some complications, like pleural effusion or deep vein thrombosis. Therefore, it remains uncertain whether a routine use of PGE 1 after head and neck microsurgery is justified. We aim to test the hypothesis that PGE 1 increases postoperative vessel patency rate in patients undergoing head and neck microsurgery, with a comparable complication rate as the control group.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

National Taiwan University Hospital

Treatments:

Alprostadil

Criteria

Inclusion Criteria:

- Patients requiring microvascular reconstruction after head and neck cancer resection

Exclusion Criteria:

- Patients with coagulation dysfunction