The Use of Sennosides With Pico Salax in Bowel Preparation for Colonoscopy: a Study of Optimal Dose and Timing

• Status: Completed
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The objective of this study is to evaluate sennosides as an adjunct to sodium picosulfate magnesium citrate (Pico Salax) in preparation for colonoscopy. We will compare different doses and administration times. The primary outcome is number of bowel motions produced. Secondary outcomes include the quality of bowel cleansing and patient tolerability.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Queen's University
• Treatments: Senna Extract; Sennoside A&B; Sennosides

Criteria

Inclusion Criteria:

• Male and non-pregnant female patients 18 to 75 years of age inclusive

• Patients who require an outpatient colonoscopy with a split dose Pico-Salax prep

Exclusion Criteria:

• Colonoscopy requiring the use of a large volume prep (eg Colyte, PEG)

• Ileus or bowel obstruction

• Previous colorectal surgery

• Ascites

• Recognized renal impairment (defined as GFR less than normal in 3 months prior to enrolment)

• Pregnancy

• Recent (<6 months) myocardial infarction or unstable angina.