The Use of an Inhaled Salt Solution to Treat Viral Lung Infections in Infants.

• Status: Completed
• Trial end date: 2006-09-01
• Target enrollment: 0
• Participant gender: All

Summary

Bronchiolitis is a common viral lung infection in infants. Standard treatment often includes the use of inhaled medications which are usually first mixed with a standard salt solution. Inhalation of a more concentrated salt solution (hypertonic saline) has been successfully used to treat other types of lung disease in children and adults. The purpose of this study is to see if using inhaled hypertonic saline helps infants with bronchiolitis get better more quickly.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sheikh Khalifa Medical City

Criteria

Inclusion Criteria:

• Corrected age maximum 18 months, plus

• History of preceding viral upper respiratory tract infection, plus

• Presence of wheezing and/or crackles on auscultation, plus

• Respiratory Distress Assessment Instrument (RDAI) score of 4 or greater, or oxygen saturation of 93% or less in room air, plus

• Admitted to hospital

Exclusion Criteria:

• Prior history of wheezing, or

• History of chronic cardiopulmonary disease or immunodeficiency, or

• Critical illness at presentation requiring admission to ICU, or

• Use of nebulized hypertonic saline within previous 12 hours, or

• Prematurity (gestational age 34 weeks or less).