Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Brain Tumor Surgery

• Status: Completed
• Trial end date: 2018-07-30
• Target enrollment: 0
• Participant gender: All

Summary

Vitamin D supplementation not only has beneficial effects on morbidity and mortality in critically ill patients but it may also lead to alleviate of seizure, brain edema, infection, pain and some other perioperative complications, possibly in part through an attenuation of the immune response.In this trial patients with brain tumor under craniotomy will receive a single high dose vitamin D compared to control group.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shahid Beheshti University
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Written informed consent of patient or legal representative

• 25(OH)D level below 20ng/dL

Exclusion Criteria:

• Other trial participation, including previous participation in the pilot trial

• Pregnant or lactating women

• Hypercalcemia

• Hyperphosphatemia

• Tuberculosis

• Sarcoidosis

• History of nephrolithiasis

• History of hyperparathyroidis

• Medications that interfere with vitamin D metabolism

• Renal Insufficiency