Therapeutic Effect of Crizotinib for Rearrangement-negative, High Phosphorylated ALK Patients

• Status: Completed
• Trial end date: 2023-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with histologically or cytologically confirmed stage IIIB or IV ALK-negative non-small-cell lung cancer (NSCLC) participated in this study following the failure of initial treatments. The ALK phosphorylation expression was detected in histologic samples of patients. patients with positive ALK phosphorylation expression were treated with crizotinib .

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Harbin Medical University
• Treatments: Crizotinib

Criteria

Inclusion Criteria:

1. Age between 18 years and 80 years

2. Histologically or cytologically confirmed stage IIIB or IV ALK-negative NSCLC by NGS

3. Disease staging determined according to the International Association for the Study of Lung Cancer 8th edition TNM staging system

4. All measurable Response Evaluation Criteria in Solid Tumors (RECIST) target lesions

5. Treatment failure at the end of the most recent treatment episode

6. World Health Organization/Eastern Cooperative Oncology Group (ECOG) performance status 0-2

7. Consent of patients for participation in this study

8. Complete clinical data

9. High ALK phosphorylation level

Exclusion Criteria:

1. Patients with cognitive impairment, severe psychiatric diseases, or other disorders likely to impact informed consent

2. Patients with uncontrolled systemic disease

3. Patients with other malignant tumors