Therapeutic Effect of Sildenafil in Patients With Coronary Vasospasm
Status:
Withdrawn
Trial end date:
2009-12-31
Target enrollment:
Participant gender:
Summary
This will be a prospective, phase IIIb, double-blind and randomized trial testing the effect
of single dose sildenafil application in patients with coronary vasospasm compared to placebo
application.
The target variable to be tested is the degree of coronary vasoconstriction in response to
intracoronary ACh application (in addition to clinical chest pain) which will be imaged by
coronary angiography and measured using quantitative coronary angiography software.
Main objective: Has sildenafil the potency to inhibit the induction of coronary vasospasm by
intracoronary ACh-application in patients with proven coronary artery spasm?
Secondary objective: Which degree of coronary vasospasm inhibition can be achieved with
sildenafil?