Therapeutic Zinc in Childhood Pneumonia

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to assess whether zinc given as adjuvant therapy to standard antibiotic treatment in children hospitalized for severe pneumonia reduces the duration of the severe illness and risk of treatment failure. A randomized double blind placebo controlled clinical trial will be conducted at the Kanti Hospital.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Centre For International Health
• Collaborators: All India Institute of Medical Sciences, New Delhi; Institut de Recherche pour le Developpement; Society for Applied Studies; Statens Serum Institut; Tribhuvan University, Nepal
• Treatments: Zinc; Zinc Sulfate

Criteria

Inclusion Criteria:

• Children aged 2- 35 months with a history of cough (duration <14days) and difficult breathing of
• Availability of informed consent.

Exclusion Criteria:

• Children with severe wasting (<70% NCHS median weight for height)

• Severe anemia (hemoglobin <7 gm/dl.)

• Presence of heart disease with or without signs of cardiac failure.

• Child with a chronic cough (lasting for ≥14 days)

• Documented tuberculosis with ongoing treatment.

• Associated other severe diseases that require special care or surgical intervention.

• Children with concomitant diarrhea with some/severe dehydration

• Children with a history of recurrent wheezing

• Children enrolled in the study within the last 6 months of this visit