Therapies on Newly Diagnosed Type 2 Diabetes Patients With High Glucose Toxicity Which Protect Islet β Cell
Status:
Unknown status
Trial end date:
2020-01-01
Target enrollment:
Participant gender:
Summary
Prevalence of diabetes is increasing rapidly both in China and all over the
world.Hyperglycemia is an important risk factor and major hazard to cardiovascular and
cerebrovascular diseases and even dangerous to human health."High glucose toxicity "cause
pancreatic β cell non-physiologic and irreversible damage.It is an important cause of β cell
dysfunction.High glucose toxicity further suppresses insulin secretion of β cell, further
even β-cell function failure.It is urgent to explore more effective and safety treatments
which can also protect islet cells function.How to release high glucose toxicity , reverse
the toxic effects of hyperglycemia on islet β cells as early as possible, and to maximize
recover and protect the pancreatic β cell function is the keypoints of this study.Our aim is
to explore the non-inferiority of new antidiabetic drugs DPP4 inhibitors on releasing glucose
toxicity and protecting islet β cell function compared with traditional treatments on newly
diagnosed type 2 diabetes,compare efficacy and safety of different oral antidiabetic drugs
and insulin on newly diagnosed type 2 diabetes patients with high glucose toxicity and
compare differences of different oral antidiabetic drugs and insulin on protecting pancreatic
β-cell function.
Phase:
N/A
Details
Lead Sponsor:
First Affiliated Hospital Xi'an Jiaotong University