Therapy Optimization Trial for the Treatment of Relapsed or Refractory Brain Tumors in Children
Status:
Completed
Trial end date:
2016-01-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to improve overall survival while maintaining a good quality of
life in pediatric patients with refractory or recurrent brain tumors (medulloblastomas,
supratentorial PNETs, ependymomas WHO grade II and III). Response to different chemotherapy
options (intravenous versus oral chemotherapy, intraventricular chemotherapy) as part of a
multimodal therapy will be assessed. Progression-free, overall survival and toxicity will be
evaluated additionally.