Therapy With Verapamil or Carvedilol in Chronic Heart Failure

• Status: Unknown status
• Trial end date: 2008-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this study is to compare the effect of treatment with verapamil or carvedilol on long-term outcomes in stable, chronic heart failure secondary to non-ischemic cardiomyopathy.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical University of Silesia
• Treatments: Carvedilol; Verapamil

Criteria

Inclusion Criteria:

• Chronic heart failure (NYHA II and III; LV ejection fraction, ≤ 35%) secondary to non-ischemic cardiomyopathy

• Stable condition at least 6 months before enrollment on conventional therapy (beta-blockers, ACE inhibitors and diuretics).

Exclusion Criteria:

• Improvement in clinical status on conventional therapy in out-patients period preceded hospitalization,

• Any changes narrowing epicardial coronary arteries in coronary angiography,

• Insulin dependent diabetes,

• Valvular heart disease (except the relative mitral regurgitation),

• Endocrine disease

• Significant renal and liver disease

• Alcohol abuse

• Lack of written informed consent