Therapy of Bronchoalveolar Lavage and Local Amikacin Injection in Patients With Acute Exacerbation of Bronchiectasis

• Status: Unknown status
• Trial end date: 2019-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The therapy of bronchoalveolar lavage and local amikacin injection as one of the treatment of bronchiectasis developed in recent years.this study is aim to evaluate the Clinical Efficacy and Safety of Therapy of Bronchoalveolar Lavage and Local Amikacin Injection in Patients with Acute Exacerbation of Bronchiectasis.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Pulmonary Hospital, Shanghai, China
• Treatments: Amikacin

Criteria

Inclusion Criteria:

1. Age≥18 years and ≤80 years;

2. Patients with non-cystic fibrosis bronchiectasis diagnosed by high-resolution CT;

3. Are sensitive to amikacin;

4. Acute exacerbation of bronchiectasis;

5. Capable of the completion of bronchoscopy, alveolar lavage, pulmonary function testing etc;

6. Willing to join in and sign the informed consent form.

Exclusion Criteria:

1. Active bleeding without control；

2. Receiving nasal or facial surgery recently；

3. With severe cardio-pulmonary dysfunction, such as left heart failure, unstable arrhythmia, etc.

4. With other respiratory diseases: such as active pulmonary tuberculosis, non-tuberculosis mycobacteria (NTM) pulmonary disease, pulmonary aspergillosis, etc.

5. Be allergic to amikacin