Thiamine Supplement in Patients With Severe Hyperthyroidism

• Status: Completed
• Trial end date: 2016-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Thyrotoxicosis is a hypermetabolic state in which there is increased utilization of thiamine. Thiamine deficiency has been observed in association with hyperthyroidism. Several studies documented that thiamine treatment could improve signs and symptoms of congestive heart failure, or even improve left ventricular ejection fraction in patients without thyrotoxicosis. This pilot study aims to evaluate prevalence of thiamine deficiency and assess improvement of cardiovascular function after receiving thiamine supplement in thyrotoxic patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ramathibodi Hospital
• Treatments: Thiamine

Criteria

Inclusion Criteria:

• Hospitalized patients with severe thyrotoxicosis

• Thyrotoxic patients with cardiovascular involvement e.g. heart rate > 90/min, atrial fibrillation or congestive heart failure

• Agree to participate by written informed consent

Exclusion Criteria:

• Previously treated with thiamine within 1 month before the enrollment

• End-stage renal disease

• Alcoholism

• Pregnant or lactating women

• Post gastric bypass surgery