Thiamine Supplementation in High Risk Cardiac Surgery Patients

• Status: Completed
• Trial end date: 2018-06-18
• Target enrollment: 0
• Participant gender: All

Summary

This pilot trial will evaluate the ability of thiamine to affect on postoperative vasoplegia in high risk cardiac surgery patients

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Meshalkin Research Institute of Pathology of Circulation
• Treatments: Thiamine

Criteria

Inclusion Criteria:

• Valve surgery + CABG that required cardiac surgery with CPB

• Aged 18 years or older

• Signed informed consent

Exclusion Criteria:

• Emergency surgery

• Chronic kidney disease of G4-G5 categories according to KDIGO criteria (at least one of the following present for > 3 months: glomerular filtration rate ≤ 29 ml/min/1.73 m2, history of kidney transplantation)

• Known allergy to thiamine

• Pregnancy

• Current enrollment into another RCT (in the last 30 days)

• Previous enrollment and randomisation into the APPLY trial

• Administration of thiamine in the previous 30 day