Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest
Status:
Recruiting
Trial end date:
2021-08-01
Target enrollment:
Participant gender:
Summary
This study is to evaluate whether thiamine can increase oxygen consumption and lower lactate
in patients who initially survive an in-hospital cardiac arrest. Patients who are
successfully resuscitated after an in-hospital cardiac arrest and who are on mechanical
ventilation in the intensive care unit will be enrolled, and will get either thiamine or
placebo. Their oxygen consumption and lactate will be measured at serial time points and
compared between groups. The investigators' hypothesis is that thiamine will help restore the
body's ability to metabolize oxygen normally (aerobic metabolism), leading to an increase in
oxygen consumption and a decrease in lactate.