This Study Tests the Effect of Certain Medicines on the Transport of Other Medicines in the Body of Healthy Men
Status:
Completed
Trial end date:
2018-05-02
Target enrollment:
Participant gender:
Summary
The primary objective of this trial is to investigate the relative bioavailabilities of
digoxin, furosemide, metformin and rosuvastatin given as a cocktail alone and as a cocktail
together with the following drug transporter inhibitors:
Part 1: verapamil (P-gp) and rifampin (OATP1B1/1B3) Part 2: cimetidine (OCT2/MATE) Part 3:
probenecid (OAT1/3) The secondary objective is to investigate other potential changes in
pharmacokinetics (e.g. in clearance, volume of distribution, etc.) of digoxin, furosemide,
metformin and rosuvastatin given as a cocktail alone and as a cocktail together with the
inhibitors describe above.