Overview

This Study Uses Ultrasound to Determine Whether Atorvastatin or Pravastatin Effects the Progression of Coronary Plaque.

Status:
Completed

Trial end date:
2000-12-01

Target enrollment:
0

Participant gender:
All

Summary

This study was designed to assess the effects on coronary artery plaque using aggressive lipid-lowering therapy versus moderate lipid-lowering therapy. A substudy will examine the effect of these treatments on brachial artery vasoactivity.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Pfizer

Treatments:

Atorvastatin
Atorvastatin Calcium
Pravastatin

Criteria

Inclusion Criteria:

- Angiographic evidence of coronary artery disease as defined by a lesion that has at
least 20% reduction in luman diameter by visual (angiographic) estimation in any
native coronary artery. LDL cholesterol equal to 125mg/dl - 210mg/dl.

Exclusion Criteria:

- Patients who are anticipated to undergo coronary bypass surgery or cardiac
transplantation during the course of the study. Known major hematologic, neoplastic,
metabolic, gastrointestinal or endocrine dysfunction.