Thoracic Paravertebral Block in Pain Management After Renal Surgery

• Status: Completed
• Trial end date: 2014-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective: The objective of the study was to assess the usefulness of ThPVB in postoperative pain management after open renal resection surgery.

Design, setting, participants: It was a prospective, randomised, open label study held in a university hospital between 08.2013-12.2014. 58 Patients enrolled in the study were scheduled for elective open renal surgery (open nephrectomy or open nephron-sparing surgery) and randomised into two groups - group PVB (n=27) and group GEN (n=31).

Interventions: PVB group received preoperative ThPVB with 0,5% bupivacaine followed by general anaesthesia. GEN group received standard general anaesthesia. Both groups were treated postoperatively with oxycodone IV PCA (patient controlled analgesia) combined with non-opioid analgesics as rescue drugs. The investigators recorded pain severity in VAS, oxycodone requirement in time points, total oxycodone requirement, and sedation levels throughout the first 48h. The investigators measured opioid related adverse events 24 and 48 h postoperatively and patients satisfaction 48h postoperatively.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Silesian University of Medicine
• Treatments: Acetaminophen; Bupivacaine; Cisatracurium; Fentanyl; Propofol; Sevoflurane

Criteria

Inclusion criteria:

• Age 18-75

• Scheduled for elective open nephrectomy or NSS

• Gave written consent

• BMI 19-30

• ASA status I-III

Exclusion criteria:

• Presence of chronic pain

• Chronic mental conditions (depression)

• Contraindications for PVB

• Chest or spine deformations

• Infection in planned site of PVB

• Allergies for drugs used in the study

• Cancer invading chest wall