Three Anticoagulation Strategies for Hemodialysis in Patients at Risk of Hemorrhage

• Status: Unknown status
• Trial end date: 2019-03-30
• Target enrollment: 0
• Participant gender: All

Summary

The aim of our study is to assess three anticoagulation strategies for intermittent hemodialysis(IHD) in patients at risk of hemorrhage. A registry of consecutive hemodialysis patients with high risk of hemorrhage was conducted at the Guangdong General Hospital, the First Affiliated Hospital of Guangzhou University of Chinese Medicine, the Second Affiliated Hospital of Guangzhou Medicine University or Guangzhou Hospital of Chinese Medicine, between Sep 10, 2017 and June 30th,2018. In this multi-center prospective and randomized study, participants were randomly divided into three groups during IHD according to different anticoagulation, including with regular saline flushes, one stage regional citrate anticoagulation (RCA) and two-stage RCA.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangdong General Hospital; Guangdong Provincial People's Hospital
• Treatments: Citric Acid; Sodium Citrate

Criteria

Inclusion Criteria:

• age>=18 years

• intermittent hemodialysis patients that carry on a 4 hours hemodialysis procedure, 2-3 times one week.

• the therapy mode is hemodialysis，with a dialysis fluid more than 500ml/min and blood flow volume more than 3.5-4ml/min.kg；

• at risk of hemorrhage,including active hemorrhage(within 3 days),post-operation(within 3 days) and pre-invasive operation(within 7 days).

Exclusion Criteria:

• at high risk of citrate accumulation( total bilirubin >60umol/L; lactic acid>3mmol/L,）；

• use the drugs that impact the coagulation function within 7 days;

• serious hypocalcemia (serum calcium<1.9mmol/L).