c. To measure a baseline for each subject, an abdominal x-ray (KUB) was performed, the SCI
Bowel Survey and Treatment Satisfaction Questionnaire (TSQM) were administered and the
subject's weight determined. After all the baseline measurements were acquired, the subjects
underwent transdermal screening with hair epilation to test their response to transdermal
administration of NEO (0.07mg/kg) and GLY (0.014mg/kg). All subjects had a positive response
(bowel movement within 60 minutes of drug administration) and received five more cycles of
bowel care for two weeks. All subjects reported bowel evacuation during each session and some
reported side effects like slight dry mouth, eye twitching, and cramping. These side effects
lasted approximately 20-30 minutes in duration and there were no clinically significant
changes in cardiopulmonary vital signs. Six subjects after completing two weeks of bowel care
had an abdominal x-ray (KUB) done. Also, they were weighted and reassessed using the TSQM and
bowel survey.