Overview
Thromboxane Function in Women With Endometriosis
Status:
Recruiting
Recruiting
Trial end date:
2027-08-01
2027-08-01
Target enrollment:
0
0
Participant gender:
Female
Female
Summary
The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: - Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? - Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: - perform hand grip exercise and cold pressor tests - undergo iontophoresis and blood draw Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Penn State UniversityTreatments:
Aspirin
Criteria
Inclusion Criteria:- Born with a uterus
- 18-45 years old
- With and without endometriosis
Exclusion Criteria:
- Currently pregnant or breastfeeding
- Diagnosed cardiovascular disease
- BMI over 35
- Nicotine use (e.g., smoking, chewing tobacco, vaping, etc.)
- Currently using hormone replacement therapy (or have used within previous 6 months)
- Known skin allergies or current rash, skin disease, disorders of pigmentation
- Diabetes
- Renal disease, renal artery stenosis, renal impairment
- Liver disease
- Stage II Hypertension (blood pressure >140/>90 mmHg)
- Hypotension (blood pressure < 90/60 mmHg)
- Raynaud's syndrome
- Any current medications which could conceivably alter cardiovascular responses (e.g.
antihypertension medication, diuretic, digoxin)
- Allergy or hypersensitivity to investigational agents
- Immunosuppressed/immunocompromised