Thromboxane Function in Women With Endometriosis

• Status: Recruiting
• Trial end date: 2027-08-01
• Target enrollment: 0
• Participant gender: Female

Summary

The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are:

• Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women?

• Do women with endometriosis have greater platelet activity than healthy women?

Participants will take aspirin and/or placebo and will:

• perform hand grip exercise and cold pressor tests

• undergo iontophoresis and blood draw

Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Penn State University
• Treatments: Aspirin

Criteria

Inclusion Criteria:

• Born with a uterus

• 18-45 years old

• With and without endometriosis

Exclusion Criteria:

• Currently pregnant or breastfeeding

• Diagnosed cardiovascular disease

• BMI over 35

• Nicotine use (e.g., smoking, chewing tobacco, vaping, etc.)

• Currently using hormone replacement therapy (or have used within previous 6 months)

• Known skin allergies or current rash, skin disease, disorders of pigmentation

• Diabetes

• Renal disease, renal artery stenosis, renal impairment

• Liver disease

• Stage II Hypertension (blood pressure >140/>90 mmHg)

• Hypotension (blood pressure < 90/60 mmHg)

• Raynaud's syndrome

• Any current medications which could conceivably alter cardiovascular responses (e.g. antihypertension medication, diuretic, digoxin)

• Allergy or hypersensitivity to investigational agents

• Immunosuppressed/immunocompromised