Overview

Thromboxane Function in Women With Endometriosis

Status:
Recruiting
Trial end date:
2027-08-01
Target enrollment:
0
Participant gender:
Female
Summary
The goal of this clinical trial is to compare neurovascular regulation in women with endometriosis and healthy women. The main questions it aims to answer are: - Do women with endometriosis have greater blood pressure and pain responses to a stimulus than healthy women? - Do women with endometriosis have greater platelet activity than healthy women? Participants will take aspirin and/or placebo and will: - perform hand grip exercise and cold pressor tests - undergo iontophoresis and blood draw Researchers will compare women with and without endometriosis to see if there is a difference in neurovascular regulation.
Phase:
Phase 4
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Penn State University
Treatments:
Aspirin
Criteria
Inclusion Criteria:

- Born with a uterus

- 18-45 years old

- With and without endometriosis

Exclusion Criteria:

- Currently pregnant or breastfeeding

- Diagnosed cardiovascular disease

- BMI over 35

- Nicotine use (e.g., smoking, chewing tobacco, vaping, etc.)

- Currently using hormone replacement therapy (or have used within previous 6 months)

- Known skin allergies or current rash, skin disease, disorders of pigmentation

- Diabetes

- Renal disease, renal artery stenosis, renal impairment

- Liver disease

- Stage II Hypertension (blood pressure >140/>90 mmHg)

- Hypotension (blood pressure < 90/60 mmHg)

- Raynaud's syndrome

- Any current medications which could conceivably alter cardiovascular responses (e.g.
antihypertension medication, diuretic, digoxin)

- Allergy or hypersensitivity to investigational agents

- Immunosuppressed/immunocompromised