Thymoglobulin: Presence and Affect in the Central Lymphatic Compartment
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
This study proposes to examine the effect of TMG therapy upon the cellular elements within
the central (bone marrow) and peripheral (lymph node) lymphoid compartments of humans.
Briefly, bone marrow aspirates and lymph nodes will be obtained at the time of transplant,
from renal transplant recipients receiving TMG induction therapy. For comparative purposes,
peripheral blood samples will also be obtained. Lymphocytes from these compartments will be
assessed for CD antigen expression, apoptosis, cytokine production following memory immune
responses, and functional assays to assess potential regulatory T-cell (Treg) activity.