Ticagrelol Versus Aspirin in Ischemic Stroke

• Status: Completed
• Trial end date: 2020-09-30
• Target enrollment: 0
• Participant gender: All

Summary

There is a debate whether ticagrelor is superior to aspirin in treating patients with ischemic stroke or not, most of the studies examine the effect of both drugs within 24 hours of acute stroke some find that there is no difference between ticagrelor and aspirin, others find that ticagrelor is superior to aspirin.

At this study the investigators aim at evaluating the role of loading ticagrelor received within 9 hours of acute ischemic stroke in improving neurological outcome of stroke. And evaluating the risk of hemorrhagic and non- hemorrhagic complications associated with the use of ticagrelor180 ml oral loading dose within 9 hours acute ischemic stroke

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kafrelsheikh University
• Collaborator: Ain Shams University
• Treatments: Aspirin; Ticagrelor

Criteria

Inclusion Criteria:

1. Male & female patients will be included

2. Age between 18 - 75 years

3. First ever presentation with acute ischemic stroke.Previous transient ischemic attacks (TIA's) are not excluding

4. Ictus to drug time does not to exceed 9 hours.

Exclusion Criteria

1. Patient eligible for recombinant tissue plasminogen activator (rTPA)

2. patients with( national institute of health stroke scale (NIHSS) below 3 or above 25

3. patients with active malignancy

4. patients with major surgery in past 3 months

5. patients with known allergy to study drugs

6. patients with acute myocardial infarction in past 6 months

7. patients known to suffer from multiple sclerosis or epilepsy

8. pregnancy or lactation

9. patients with history of head trauma with residual neurological deficits

10. patients on regular ticagrelol in past week

11. patients with international normalized ratio (INR) more than 1.3 or prothrombin time (PT) more than 18

12. patients with venous thrombosis

13. patients with platelet count less than 100000 or white blood cells (WBCs) less than 3000 or hematocrit value less than 0.25

14. blood glucose less than 50 mg/DL or more than 400