Ticagrelor and Endothelial Function

• Status: Unknown status
• Trial end date: 2015-11-01
• Target enrollment: 0
• Participant gender: All

Summary

To evaluate the effect of ticagrelor on endothelial function as measured by flow mediated dilation of the brachial artery. This will be compared to prasugrel.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hotel Dieu de France Hospital
• Treatments: Prasugrel Hydrochloride; Ticagrelor

Criteria

Inclusion Criteria:

• - Prior MI > 1 year old

• Prior PCI > 1 year old

• Prior CABG > 3 months old

• Known lesion causing more than 50% stenosis on coronary angiography

Exclusion Criteria:

• Acute coronary syndrome within the last 6 months

• Any history of bleeding

• Age > 75 years

• Weight < 65 kg

• Prior stroke or TIA

• Platelet count < 100,000

• Hemoglobin < 11 mg/dL

• Patients who have received ticagrelor, prasugrel or clopidogrel in the 3 months that preceded randomization

• Patients who are taking anti-thrombotic therapy