Tight Glycemic Control During Angioplasty Revascularization Reduces Coronary Stent Restenosis

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

A multicentric study will evaluate whether peri-procedural tight glycemic control during angioplasty revascularization for acute coronary syndrome (ACS) reduces circulating inflammatory cytokines and thrombus formation in hyperglycaemic patients. Moreover, the investigators will assess whether the tight glycemic control during the first month from coronary event reduces the incidence of coronary stent restenosis at 6-months from PCI.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second University of Naples; University of Campania "Luigi Vanvitelli"
• Treatments: Insulin; Insulin, Globin Zinc

Criteria

Inclusion Criteria:

• chest discomfort lasting at least 15 min within the last 24 h,

• new >l mm ST-wave or dynamic T-wave changes in at least two contiguous ECG leads,

• troponin I levels above the 99th percentile 6-12 h after the onset of chest pain

• patients referred to the cardiac catheterization laboratory within 24 h of symptoms.

Exclusion Criteria:

• left ventricular ejection fraction less than 25%,

• hemorrhagic diatheses,

• contraindications or allergy to aspirin, thienopyridines, and history of anaphylaxis in response to iodinated contrast medium,

• serum creatinine level of more than 2.0 mg/dl (177 μmol/l),

• leukocyte count of less than 3500/mm3, platelet count of less than 100,000/mm3

• coexisting conditions that limited life expectancy to less than 24 months or that could affect a patient's compliance with the protocol.