Tight Glycemic Control With Intensive Insulin Therapy in PICU
Status:
Unknown status
Trial end date:
2021-06-01
Target enrollment:
Participant gender:
Summary
In a previous study, the investigators showed that tight blood glucose control with insulin
during intensive care reduced morbidity and mortality in adult intensive care patients.
Whether this intervention also improves prognosis of pediatric intensive care patients
remains unknown. The current prospective, randomized, controlled study will asses the impact
of intensive insulin therapy on outcome of patients in a pediatric intensive care unit. On
admission patients will be randomly assigned to either strict normalization of blood glucose
according age adjusted values or the conventional approach, in which insulin infusion is
initiated only when blood glucose exceeds 215 mg/dl to maintain blood glucose levels between
180-200 mg/dl.