Tight Hemodynamic Control in Patients Who Are Chronically on Metoprolol
Status:
Terminated
Trial end date:
2013-12-01
Target enrollment:
Participant gender:
Summary
This study proposes to assess the effect of the standard of care, which is continuation of
the pre op beta blocker dose into the post operative period compared to the administration of
esmolol titrated to a pre determined target HR. The primary outcome will compare
postoperative plasma levels of metoprolol in 2 cohorts in a group who has been continued on
metoprolol (administrated via a nasogastric tube in NPO patients) to a group who has been
withdrawn from metoprolol but given an esmolol infusion titrated to HR. Secondary outcomes
will compare a) the hemodynamic responses, documenting the incidence of unplanned hypotension
and bradycardia and b) to compare the effects of Heart rate to the incidence of myocardial
ischemia, arrhythmias, delirium and infarction.