Tight Intra-Operative Glucose Control During Coronary Artery Bypass Surgery
Status:
Terminated
Trial end date:
2009-08-01
Target enrollment:
Participant gender:
Summary
Blood glucose levels increase in response to stress, infection or other conditions faced by
patients in the hospital. This occurs commonly among patients with known diabetes, but also
among non-diabetic hospitalized patients. Tight glucose control, the maintenance of blood
glucose levels within normal limits (80-120 mg/dl), has been shown to improve patient
outcomes in the hospital in several settings, mainly among critically ill patients
hospitalized in intensive care units.
We plan to assess the importance of tight glucose control during open-heart surgery. The
prevalence of hyperglycemia (elevated blood glucose) during this operation is high.
Hyperglycemia may be associated with increased vulnerability to surgical site infections,
neurological damage, cardiac and renal injury. Conversely, tight glucose control may be
associated with hypoglycemia (pathologically low glucose levels) that may results in
neurological injury. We hypothesize that tight glucose control will improve patient outcomes
following surgery.