Overview

Timing of Initiation of Luteal Phase Support in Poor Responders Undergoing IVF/ICSI

Status:
Unknown status
Trial end date:
2021-07-01
Target enrollment:
0
Participant gender:
Female
Summary
It is already known that all stimulated IVF ICSI cycles needs luteal phase support for higher pregnancy rates The current study will focus on evaluating two different starting times of luteal phase support
Phase:
Phase 4
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Ain Shams Maternity Hospital
Collaborator:
Ahmed Mahmoud Abdel-Rahim
Treatments:
Progesterone
Criteria
Inclusion Criteria:

- At least two of the following three features must be present Advanced maternal age (40
years) or any other risk factor for Poor Ovarian Response

A previous POR (≤3 oocytes with a conventional stimulation protocol):

An abnormal ovarian reserve test (ORT): (i.e. AFC< 5-7 follicles or AMH 0.5-1.1ng/ml Two
episodes of POR after maximal stimulation are sufficient to define a patient as poor
responder in the absence of advanced maternal age or abnormal ORT By definition, the term
POR refers to the ovarian response and, therefore, one stimulation cycle is considered
essential for the diagnosis of POR, However, patients over 40 years of age with abnormal
ORT may be classified as poor responders since both advanced age and an abnormal ORT may
indicate reduced ovarian reserve and act as surrogate of ovarian stimulation cycle. in this
case, the patients should be more properly defined as expected PORs

Exclusion Criteria:

- - Severe husband semen oligo terato atheno spermia

- Abnormal karyotyping of one or both couples

- Congenital and acquired uterine abnormalities

- Antiphospholipid Antibody syndrome

- Untreated hydrosalpinx

- Women intending to do PGD or screening

- Thin endometrium (< 7 mm) at day of HCG

- Premature luteinization (P> 2 ng/ml or P/E2 ratio > 1 on the day of HCG)

- Ovarian follicle > 10 mm and/or E2 > 40 pg/ml at day2 of stimulation cycle

- Less than two follicles (≥ 17mm) and/or E2 < 500 pg/ml at day of HCG