Timolol Eye Drops in the Treatment of Acute Migraine Headache

• Status: Terminated
• Trial end date: 2017-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to determine whether timolol eye drops are effective in alleviating acute migraine headaches. Subjects will be randomized to receive either timolol eye drops or placebo (tears) to use as a migraine abortive medication.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Missouri, Kansas City
• Collaborator: Truman Medical Center
• Treatments: Lubricant Eye Drops; Ophthalmic Solutions; Tetrahydrozoline; Timolol

Criteria

Inclusion Criteria:

• Diagnosis of migraine headache

Exclusion Criteria

• Non-migraine headache

• Use of systemic beta-blocker

• Medical history of hypotension, bradycardia, syncope or other significant cardiovascular disease

• Medical history of difficulty breathing, asthma or chronic obstructive pulmonary disease or other pulmonary disease

• Medical history of glaucoma, ocular hypertension or hypotony, punctual stenosis, current use of other ophthalmic medications

• Previous adverse reaction to timolol or other beta-blockers

• Inability to self-administer eye drop due to physical or cognitive disorders

• Currently pregnant or breastfeeding

• Pregnant in the past year

• Non-english speaker