Tinnitus Treatment With Piribedil Guided by Acoustic Otoemissions and Electrocochleography
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Tinnitus is defined as the perception of sound in the absence of a external source. About 15
% of the population is believed to experience tinnitus and for about 20 % of them it may
become a very serious problem. Total comprehension of tinnitus pathophysiology has not yet
been achieved, but modern theories focus in brain hyperactivity following inner ear damage,
with involvement of various neurotransmitters. Piribedil,a dopamin agonist, has been used to
treat tinnitus, focusing in dopamine release, which is inhibitory. Electrophysiological
methods,like acoustic otoemissions and electrocochleography may reveal the changes in
peripherical and central auditory pathways and help to choose the specific patients who could
benefit from piribedil treatment.