Tirofiban Intracoronary Bolus-only Versus Intravenous Bolus Plus Infusion in STEMI Patients

• Status: Completed
• Trial end date: 2009-08-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this randomized trial is to compare the efficacy of high dose tirofiban administered as either an intracoronary bolus alone or as an intravenous bolus followed by a maintenance infusion with respect to microvascular perfusion and long term left ventricular infarct size, volumes and function.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kosuyolu Heart Hospital
• Collaborator: The Society of Cardiac Health Protection
• Treatments: Tirofiban

Criteria

Inclusion Criteria:

• Typical ongoing ischemic chest pain for longer than 30 minutes

• ST segment elevation of 0,1 mV or greater in at least two contiguous leads or a new left bundle branch block on the initial ECG.

Exclusion Criteria:

• Cardiogenic shock and / or clinical instability

• previous STEMI

• Malignant life threatening diseases

• Presence of an additional lesion causing more than 50% narrowing distal to the culprit lesion

• Contraindications to aspirin, clopidogrel, or heparin

• inability to give informed consent.