Herniorrhaphy is the most frequent general surgical procedure. There are moderate pain
complaints after herniorrhaphy. Besides causing discomfort to the patients, pain, can delay
recovery and discharge and cause cognitive dysfunction and difficulty with returning to
normal daily activity.
A combination of analgesics with different effect sites can reduce the doses needed and
analgesic related side effects which is called multimodal analgesia .
Opioids, acetaminophen, nonsteroid anti-inflammatory drugs and cox-2 inhibitors, alfa-2
receptor agonists, steroids, gabapentin and pregabalin have been used for this purpose(4).
Tizanidine is an alfa-2 receptor agonist, and is used for musculoskeletal pain conditions.
Tizanidine reduced the local anesthetic requirement in spinal anesthesia.
The aim of this study is to investigate the hypothesis that: Tizanidine can reduce the pain
scores, analgesic consumption, analgesic related side effects and provide early return to
normal daily activity compared to placebo after inguinal herniorrhaphy.