To Assess the Role of Fecal Microbiota Transplant in Acute Liver Failure
Status:
Withdrawn
Trial end date:
2020-12-31
Target enrollment:
Participant gender:
Summary
All patients of Acute liver failure not meeting the KCH (King's College Hospital) criteria/or
meeting KCH criteria not having option of liver transplant will be recruited for the trial.
The first group will receive Standard medical care with Fecal Microbiota transplant on Day 1
for 3 consecutive days. FMT (Fecal Microbiota Transplant) will be delivered rectally which
will be placed bedside. Suitable donor will be screened and the stool samples will be used as
per criteria. Stool samples will be taken at the time at Day 0, 1(Post FMT), Day 4, 6, 14,21.
Sepsis screen will be sent. Inflammatory markers will be sent on Day 0,1, 4,6, 14,21. The
second group will receive standard medical therapy/and an placebo. Stool samples will be sent
on Day 0,1, 4, 6 , 14,21. Inflammatory markers will be sent on the time on day 0,1 4,6 ,
14,21.