To Compare the Pulpal Oxygen Saturation Level After Administering Mepivacaine With and Without Vasoconstrictor

• Status: Completed
• Trial end date: 2019-11-19
• Target enrollment: 0
• Participant gender: All

Summary

As vasoconstrictors adversely affect pulpal hemodynamics, this study compared the pulpal oxygen saturation levels after employing inferior alveolar nerve block with 2% mepivacaine with 1:100,000 epinephrine (2% Scandonest Special) and 3% mepivacaine (3% Scandonest Plain).Two groups were made with 30 patients in each group. 2% mepivacaine with 1:100,000 epinephrine (2% Scandonest Special) was administered to the patients in Group A whereas 3% mepivacaine (3% Scandonest Plain) was administered to the patients in Group B. Rubber dam application, cavity preparation and composite filling was then done on the selected carious mandibular premolar. Pulpal oxygen saturation levels were recorded after administration of local anesthesia with Nellcor-550 pulse oximeter and Nellcor D-YS Multisite reusable sensor.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Afshan Amjad Ali
• Treatments: Epinephrine; Mepivacaine

Criteria

Inclusion Criteria:

• Medical status: healthy individuals with no current and past medical findings.

• Medications: no current medications.

• Both mature vital ipsilateral mandibular premolars:

• Healthy premolar (ICDAS code 0)

• Carious premolar (ICDAS code 4-6).

• Periapical status

• Healthy premolar - Periapical Index. (Code 1).

• Carious premolar - Periapical Index. (Code 1).

• Periodontal status

• Healthy premolar - Classification of periodontal diseases and conditions (Code 0).

• Carious premolar - Classification of periodontal diseases and conditions (Code 0).

Exclusion Criteria:

• Patients with oral and maxillofacial syndromes and anomalies.

• Pregnant and nursing mothers.

• Class V carious lesions (sensor of pulse oximeter was placed on intact buccal, lingual and cervical surfaces).

• Teeth with extracoronal restorations.

• Teeth with developmental defects and other anomalies.

• Dental trauma.

• Teeth with symptoms of irreversible pulpitis.