To Describe the Effect of rhLH Supplementation in Women With Hyporesponse to rhFSH After Pituitary Downregulation

• Status: Unknown status
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

Primary objective:

To evaluate the efficacy in terms of oocyte retrieval number of rLH supplement in women with hyporesponse to rFSH after pituitary downregulation.

Secondary objective:

To further explore the efficacy of rLH supplement in women with hyporesponse to rFSH after pituitary downregulation To evaluate the safety of rLH supplementation in hyporesponse women

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Peking University Third Hospital
• Collaborators: Chongqing Health Center for Women and Children; Peking Union Medical College Hospital; Reproductive & Genetic Hospital of CITIC-Xiangya; The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Criteria

Inclusion Criteria:

1. 20-40 years old women

2. With menstrual cycles ranged 24-35 days, intraindividual variability±3 days

3. Basal FSH <10 IU/L at cycle D2-D5

4. 18 < BMI < 30

5. Presence of two ovaries

6. No ovarian stimulation over the past 3 months

7. Signed inform consent form.

Exclusion Criteria:

1. Polycystic ovarian syndrome

2. rAFS stage Ⅲ-Ⅳ endometriosis

3. Chromosomal abnormalities, endocrinological and/or autoimmune disorders.

4. More than two previously unsuccessful IVF.