Overview

To Determine the Feasibility of a Clinical Trial Comparing Anticoagulants Versus Antiplatelets in the Acute Treatment of Patients With Cervical Artery Dissection

Status:
Completed
Trial end date:
2014-05-01
Target enrollment:
0
Participant gender:
All
Summary
This is a feasibility study to determine if a sufficient number of patients can be recruited throughout the United Kingdom and whether sufficient endpoints can be generated for a full scale therapeutic trial of anticoagulants versus antiplatelets in acute cervical artery dissection treatment.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
St George's, University of London
Collaborator:
The Stroke Association, United Kingdom
Treatments:
Anticoagulants
Aspirin
Calcium heparin
Clopidogrel
Dipyridamole
Heparin
Ticlopidine
Warfarin
Criteria
Inclusion Criteria:

1. Extracranial carotid or vertebral artery dissection with symptom onset within the last
7 days. This includes:

1. Ipsilateral transient ischemic attack or stroke

2. Ipsilateral Horner's syndrome or neck pain with known date of onset.

2. Imaging evidence of definite or probable dissection on MRI/MRA, CTA or ultrasound.

Exclusion Criteria:

1. Intracranial cerebral artery dissection

2. Symptom onset after 7 days

3. Contraindication to either antiplatelet agents or anticoagulation therapy

4. Patient's refusal to consent

5. Patients who are undergoing angiography and stenting or surgery for treatment of their
dissection.